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英文名称： DENND1B Antigen (Recombinant Protein)
别 名： DENN domain containing 1B; FAM31B; C1ORF18; C1orf218
概 述
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Full name: |
DENN domain containing 1B |
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Synonyms: |
FAM31B; C1ORF18; C1orf218 |
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Swissprot: |
Q6P3S1 |
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Gene Accession: |
BC022561 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). |
