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中文名称： COMT 抗原（重组蛋白）
英文名称： COMT Antigen (Recombinant Protein)
别 名： catechol-O-methyltransferase; HEL-S-98n
相关类别： 抗原
概 述
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Full name: |
catechol-O-methyltransferase |
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Synonyms: |
HEL-S-98n |
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Swissprot: |
P21964 |
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Gene Accession: |
BC011935 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. |
