BTK抗原（重组蛋白）

Full name:

Bruton tyrosine kinase

Synonyms:

AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1

Swissprot:

Q06187

Gene Accession:

BC109079

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.