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  • BLNK抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW16312
    • 应用 : 仅限于科研使用
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    • 货期 : 现货
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中文名称: BLNK抗原(重组蛋白)

英文名称: BLNK Antigen (Recombinant Protein)

别       名: B-cell linker; bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65

相关类别: 抗原

储      存: 冷冻(-20℃)

概述

Fusion protein corresponding to a region derived from 257-456 amino acids of human BLNK

技术规格

Full name:

B-cell linker

Synonyms:

bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65

Swissprot:

Q8WV28

Gene Accession:

BC018906

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.