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中文名称：ARC抗原（重组蛋白）
英文名称：ARC Antigen (Recombinant Protein)
别 名： Arg3.1
储 存： 冷冻（-20℃）
相关类别：抗原
概 述：
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Fusion protein corresponding to a region derived from C terminal 298 amino acids of human ARC |
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Full name: |
activity-regulated cytoskeleton-associated protein |
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Synonyms: |
Arg3.1 |
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Swissprot: |
Q7LC44 |
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Gene Accession: |
BC012321 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Arc (for activity-regulated cytoskeleton-associated protein) is a growth factor and immediate early gene that is enriched in brain. Arc mRNA and protein levels are induced by neuronal activity, which is necessary to stimulate neuroplasticity, indicating a potential role for Arc in activity-dependent changes in dendrite function. Arc expression has been detected in neuronal cell bodies and dendrites in the hippocampus, amygdala, hypothalamus, striatum and cortex. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum. |
