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中文名称：ACVR1抗原（重组蛋白）
英文名称： ACVR1 Antigen (Recombinant Protein)
别 名： FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from 260-509 amino acids of human ACVR1 |
技术规格：
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Full name: |
activin A receptor type I |
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Synonyms: |
FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2 |
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Swissprot: |
Q04771 |
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Gene Accession: |
BC033867 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
