兔抗CRK多克隆抗体

Background:

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Applications:

ELISA, IHC

Name of antibody:

CRK

Immunogen:

Fusion protein of human CRK

Full name:

v-crk avian sarcoma virus CT10 oncogene homolog

Synonyms：

p38; CRKII

SwissProt:

P46108

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer

IHC Recommend dilution:

50-200