兔抗COX17多克隆抗体

Background:

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.

Applications:

ELISA, IHC

Name of antibody:

COX17

Immunogen:

Synthetic peptide of human COX17

Full name:

COX17 cytochrome c oxidase copper chaperone

SwissProt:

Q14061

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human prostate cancer

IHC Recommend dilution:

40-250