兔抗COL11A2多克隆抗体

Background:

This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.

Applications:

IHC

Name of antibody:

COL11A2

Immunogen:

Synthesized peptide derived from internal of human Collagen XI α2.

Full name:

collagen, type XI, alpha 2

Synonyms：

HKE5; PARP; STL3; FBCG2; DFNA13; DFNB53

SwissProt:

P13942

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100