兔抗AIFM1多克隆抗体

Background:

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Applications:

ELISA, WB, IHC

Name of antibody:

AIFM1

Immunogen:

Fusion protein of human AIFM1

Full name:

apoptosis-inducing factor, mitochondrion-associated, 1

Synonyms：

AIF, PDCD8, COXPD6

SwissProt:

O95831

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human liver cancer and human colon cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

67 kDa

WB Positive control:

NIH/3T3 , Hela and 293T cells

WB Recommended dilution:

500-2000