兔抗CLDN18多克隆抗体

Background:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Applications:

ELISA, IHC

Name of antibody:

CLDN18

Immunogen:

Synthetic peptide of human CLDN18

Full name:

claudin 18

Synonyms:

SFTA5; SFTPJ

SwissProt:

P56856

ELISA Recommended dilution:

500-1000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

10-50