兔抗GDF15多克隆抗体

Background:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.

Applications:

ELISA, IHC

Name of antibody:

GDF15

Immunogen:

Fusion protein of human GDF15

Full name:

growth differentiation factor 15

Synonyms:

PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15

SwissProt:

Q99988

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

150-300