兔抗CHIT1多克隆抗体

Background:

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

CHIT1

Immunogen:

Fusion protein of human CHIT1

Full name:

chitinase 1

Synonyms:

CHI3; CHIT; CHITD

SwissProt:

Q13231

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

52 kDa

WB Positive control:

Human lung tissue and Human spleen tissue lysates

WB Recommended dilution:

200-1000