兔抗GCH1多克隆抗体

Background:

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Applications:

ELISA, WB, IHC

Name of antibody:

GCH1

Immunogen:

Synthetic peptide of human GCH1

Full name:

GTP cyclohydrolase 1

Synonyms：

GCH, DYT5, DYT14, DYT5a, GTPCH1, HPABH4B, GTP-CH-1

SwissProt:

P30793

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human breast cancer

IHC Recommend dilution:

5-20

WB Predicted band size:

28 kDa

WB Positive control:

Human fetal liver tissue

WB Recommended dilution:

500-2000