小鼠抗PRDX5单克隆抗体

Background:

Peroxiredoxin-5 (PRDX5) is a novel mammalian peroxiredoxin, belonging to the family of thiol-dependent peroxidases. It is structurally dissimilar from other peroxiredoxins in that it contains a conserved cysteine 47 residue at the N-terminus and a cysteine 151 residue at the C-terminus which form an intramolecular disulphide bridge and confers unique chemical characteristics to this enzyme. Peroxiredoxins protect cells from apoptosis induced by overexposure to endogenous or exogenous peroxides, such as peroxynitrites, hydrogen peroxide, and alkyl hydroperoxides. Peroxiredoxin-5 is widely expressed in various subcellular regions, including mitochondria, peroxisomes, nucleus, and cytosol.

Applications:

WB, IHC

Name of antibody:

PRDX5

Immunogen:

Fusion protein of human PRDX5

Full name:

peroxiredoxin 5

Synonyms:

PLP; ACR1; B166; PRXV; PMP20; PRDX6; prx-V; SBBI10; AOEB166; HEL-S-55

SwissProt:

P30044

IHC positive control:

Human appendix tissue and Human gastric tissue

IHC Recommend dilution:

100-250

WB Predicted band size:

22 KD

WB Positive control:

Hela, HepG2, MCF7 cell lysates

WB Recommended dilution:

500-2000