小鼠抗PIK3CG单克隆抗体

Background:

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq, Jul 2008].

Applications:

WB, IHC, IF

Name of antibody:

PIK3CG

Immunogen:

Fusion protein of human PIK3CG

Full name:

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma (PIK3CG), transcript variant 1

Synonyms:

p110gamma; p120-PI3K; PI3CG; PI3K; PI3Kgamma; PIK3

SwissProt:

P48736

IHC positive control:

adenocarcinoma of human ovary tissue and human pancreas tissue; human kidney tissue and human liver tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

126 kDa

WB Positive control:

SVT2, COS7 cell lysates

WB Recommended dilution:

200-1000