小鼠抗PARP1(Cleaved)单克隆抗体

Background:

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Applications:

WB, IHC

Name of antibody:

PARP1(Cleaved)

Immunogen:

Fusion protein of human PARP1

Full name:

poly(ADP-ribose) polymerase 1

Synonyms:

PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1

SwissProt:

P09874

IHC positive control:

Human tonsil and Human esophagus cancer; Human thyroid cancer

IHC Recommend dilution:

100-500

WB Predicted band size:

113 kDa

WB Positive control:

293T cell lysate

WB Recommended dilution:

1000-5000