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021-54845833/15800441009
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Background: |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. |
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Applications: |
ELISA, WB |
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Name of antibody: |
STAT6 |
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Immunogen: |
Fusion protein of human STAT6 |
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Full name: |
signal transducer and activator of transcription 6 |
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Synonyms: |
STAT6B; STAT6C; D12S1644; IL-4-STAT |
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SwissProt: |
P42226 |
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WB Predicted band size: |
94 kDa |
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WB Positive control: |
HeLa whole cell lysate |
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WB Recommended dilution: |
1000-5000 |
