小鼠抗SPTAN1单克隆抗体

Background:

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

Applications:

WB, IHC

Name of antibody:

SPTAN1

Immunogen:

Fusion protein of human SPTAN1

Full name:

spectrin alpha, non-erythrocytic 1

Synonyms:

NEAS; EIEE5; SPTA2

SwissProt:

Q13813

IHC positive control:

Human colon tissue and Human liver cancer; Human liver tissue and Human pancreas tissue

IHC Recommend dilution:

500-2000

WB Predicted band size:

285 KD

WB Positive control:

Hela, Jurkat, SH-SY5Y cell lysates

WB Recommended dilution:

500-2000