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    小鼠抗PYM1单克隆抗体

    小鼠抗PYM1单克隆抗体

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    • 品牌 : 通蔚生物
    • 目录号 : TW11799
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
    • 商品库存：20
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中文名称： 小鼠抗PYM1单克隆抗体

英文名称： Anti-PYM1 mouse monoclonal antibody

别    名： PYM

相关类别： 一抗

储    存： 冷冻（-20℃） 避光

宿    主： Mouse

抗    原： PYM1

反应种属： Human

标 记 物： Unconjugate

克隆类型： mouse monoclonal

技术规格

Background:

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

Applications:

WB

Name of antibody:

PYM1

Immunogen:

Fusion protein of human PYM1

Full name:

PYM homolog 1, exon junction complex associated factor

Synonyms:

PYM; WIBG

SwissProt:

Q9BRP8

WB Predicted band size:

23 kDa

WB Positive control:

MCF-7 cell lysate

WB Recommended dilution:

200-1000