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  • ICOS抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW11789
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称:ICOS抗原(重组蛋白)

英文名称:ICOS Antigen (Recombinant Protein)

别      名:AILIM, CD278, CVID1

储      存:冷冻(-20℃)

相关类别:抗原

概述

Fusion protein corresponding to a region derived from 21-140 amino acids of human ICOS


技术规格

Full name:

inducible T-cell co-stimulator

Synonyms:

AILIM, CD278, CVID1

Swissprot:

Q9Y6W8

Gene Accession:

BC028006

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.