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021-54845833/15800441009
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Background: |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. |
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Applications: |
ELISA, WB |
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Name of antibody: |
PTPN11 |
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Immunogen: |
Fusion protein of human PTPN11 |
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Full name: |
protein tyrosine phosphatase, non-receptor type 11 |
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Synonyms: |
CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3 |
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SwissProt: |
Q06124 |
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WB Predicted band size: |
68 kDa |
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WB Positive control: |
HEK293 whole cell lysate |
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WB Recommended dilution: |
1000-5000 |
