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021-54845833/15800441009
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Background: |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. |
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Applications: |
ELISA, WB |
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Name of antibody: |
PSMD4 |
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Immunogen: |
Fusion protein of human PSMD4 |
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Full name: |
proteasome 26S subunit, non-ATPase 4 |
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Synonyms: |
AF; ASF; S5A; AF-1; MCB1; Rpn10; pUB-R5 |
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SwissProt: |
P55036 |
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WB Predicted band size: |
41 kDa |
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WB Positive control: |
Jurkat whole cell lysate |
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WB Recommended dilution: |
500-2000 |
