Background: |
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). |
Applications: |
WB |
Name of antibody: |
PRTN3 |
Immunogen: |
Fusion protein of human PRTN3 |
Full name: |
proteinase 3 |
Synonyms: |
MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA |
SwissProt: |
P24158 |
WB Predicted band size: |
28 KD |
WB Positive control: |
Human spleen tissue lysate |
WB Recommended dilution: |
200-1000 |