小鼠抗NME1单克隆抗体

Background:

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

Applications:

WB

Name of antibody:

NME1

Immunogen:

Fusion protein of human NME1

Full name:

NME/NM23 nucleoside diphosphate kinase 1

Synonyms:

NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1

SwissProt:

P15531

WB Predicted band size:

17 kDa

WB Positive control:

A549, MCF7, 3T3, C6 and Hela cell lysates

WB Recommended dilution:

1000-5000