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Fusion protein corresponding to a region derived from 14-324 amino acids of human HDAC8 |
技术规格
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Full name: |
histone deacetylase 8 |
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Synonyms: |
HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1 |
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Swissprot: |
Q9BY41 |
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Gene Accession: |
BC050433 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. |
