兔抗LRP1多克隆抗体

Background:

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.

Applications:

ELISA, WB, IHC

Name of antibody:

LRP1

Immunogen:

Synthetic peptide of human LRP1

Full name:

LDL receptor related protein 1

Synonyms:

APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1

SwissProt:

Q07954

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human tonsil

IHC Recommend dilution:

50-200

WB Predicted band size:

505 kDa

WB Positive control:

Mouse brain tissue, Human cerebrum tissue lysates

WB Recommended dilution:

500-2000