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帮助
021-54845833/15800441009
技术规格
Background:
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
Applications:
WB, IHC, IF
Name of antibody:
LMTK2
Immunogen:
Synthesized peptide derived from internal of human LMTK2.
Full name:
lemur tyrosine kinase 2
Synonyms：
BREK; KPI2; LMR2; cprk; KPI-2; AATYK2; PPP1R100
SwissProt:
Q8IWU2
IHC positive control:
Human brain tissue
IHC Recommend dilution:
50-100
WB Predicted band size:
165 kDa
WB Positive control:
LOVO cells lysate
WB Recommended dilution:
500-3000
IF positive control:
HepG2 cells
IF Recommend dilution:
100-500
