兔抗KSR2多克隆抗体

Background:

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Applications:

WB, IF

Name of antibody:

KSR2

Immunogen:

Synthesized peptide derived from internal of human KSR2.

Full name:

kinase suppressor of ras 2

Synonyms：

0

SwissProt:

Q6VAB6

WB Predicted band size:

108 kDa

WB Positive control:

COS7,293,3T3 cell lysates

WB Recommended dilution:

500-3000

IF positive control:

Hela cells

IF Recommend dilution:

100-500