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Fusion protein corresponding to a region derived from 718-950 amino acids of human ERBB4 |
技术规格
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Full name: |
erb-b2 receptor tyrosine kinase 4 |
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Synonyms: |
HER4; ALS19; p180erbB4 |
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Swissprot: |
Q15303 |
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Gene Accession: |
BC112199 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. |
