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021-54845833/15800441009
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Fusion protein corresponding to C terminal 300 amino acids of human DOK1 |
技术规格
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Full name: |
docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
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Synonyms: |
P62DOK |
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Swissprot: |
Q99704 |
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Gene Accession: |
BC114440 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
