兔抗KCNH1多克隆抗体

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Applications:

ELISA, IHC

Name of antibody:

KCNH1

Immunogen:

Synthetic peptide of human KCNH1

Full name:

potassium channel, voltage gated eag related subfamily H, member 1

Synonyms：

EAG; EAG1; TMBTS; h-eag; Kv10.1

SwissProt:

O95259

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and human thyroid cancer

IHC Recommend dilution:

25-100