兔抗KCNA1多克隆抗体

Background:

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

Applications:

ELISA, WB, IHC

Name of antibody:

KCNA1

Immunogen:

Synthetic peptide of human KCNA1

Full name:

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

Synonyms：

EA1, MK1, AEMK, HBK1, HUK1, MBK1, RBK1, KV1.1

SwissProt:

Q09470

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

15-50

WB Predicted band size:

56 kDa

WB Positive control:

Human brain malignant glioma tissue

WB Recommended dilution:

500-2000