兔抗ACTN4多克隆抗体

Background:

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.

Applications:

ELISA, WB, IHC

Name of antibody:

ACTN4

Immunogen:

Fusion protein of human ACTN4

Full name:

actinin, alpha 4

Synonyms：

FSGS; FSGS1; ACTININ-4

SwissProt:

O43707

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human esophagus cancer and Human thyroid cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

105 kDa

WB Positive control:

Lovo cells and mouse kidney tissue, 231 and hepG2 cells

WB Recommended dilution:

500-2000